As the severity increases, both serum T3 and T4 levels drop and gradually normalize as the patient recovers.
Euthyroid sick syndrome free#
The most prominent alterations are low serum triiodothyronine (T3) and elevated reverse T3 (rT3), leading to the general term "low T3 syndrome." Thyroid-stimulating hormone (TSH), thyroxine (T4), free T4 (FT4), and free T4 index (FTI) also are affected in variable degrees based on the severity and duration of the non-thyroidal illness. Such changes may be a self-protective adaptation to illness, as the body attempts to conserve energy. T3 is the biologically active thyroid hormone and its low serum levels in critical illness reflect altered thyroid homeostasis and a mechanism of adaptation.
The fact that the syndrome is not caused by an intrinsic abnormality in thyroid function has lead to the definition of “Non-Thyroidal Illness Syndrome”. The most common abnormality results in low T3 thyroid hormone with progressive decrease in thyroxine (T4) and TSH. Euthyroid Sick Syndrome (or Low T3 Syndrome or Non-Thyroidal Illness Syndrome) is a condition of abnormal thyroid hormones release in patients with apparently normal thyroid gland during severe systemic illness, physical trauma, and psychiatric disturbances.
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